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M94A2904.TXT
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1994-10-25
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Document 2904
DOCN M94A2904
TI Predictive factors of sequelae in AIDS patients with brain
toxoplasmosis.
DT 9412
AU Perez-Cecilia E; Sanchez J; Jimenez-Escrig A; Roca V; Romero J; Palau E;
Picazo J; Hospital Clinico, Madrid, Spain.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):198 (abstract no. PB0222). Unique
Identifier : AIDSLINE ICA10/94369671
AB OBJECTIVE: To determine predictive factors of sequelae, in AIDS patients
(pts) with brain toxoplasmosis (BT), properly treated. METHODS: 33 pts
diagnosed of BT were included. Diagnosis was based in clinical and
imaging criteria and a positive response to antitoxoplasma therapy
(91%), or a pathological proven disease (9%). No pt was in coma at the
time of diagnosis. Variables evaluated were age, sex, risk factors for
HIV infection, clinical, biochemical and image variables, immunological
status, and evolution of the disease. RESULTS: 3(9%) pts died in the
initial 30-days of disease. From the 30 survivals, 7 (23%) developed
sequelae: 3 cognitive impairment, 2 ataxia and 2 dystonia. CD4-cell
count was not related with sequelae. Variables significantly related
with the presence of sequelae were: TABULAR DATA, SEE ABSTRACT VOLUME.
CONCLUSIONS: The factors predictive of sequelae in AIDS pts with BT in
our sample were: longer evolution of disease and presence of
nonenhancing lesions and posterior fossa lesions. In these patients with
ominous factors, new treatment of BT should be assayed.
DE Ataxia/EPIDEMIOLOGY/*ETIOLOGY AIDS-Related Opportunistic
Infections/BLOOD/*COMPLICATIONS/ RADIOGRAPHY Cognition
Disorders/EPIDEMIOLOGY/*ETIOLOGY Cranial Fossa, Posterior
Dystonia/EPIDEMIOLOGY/*ETIOLOGY Human Leukocyte Count Risk Factors
Time Factors Tomography, X-Ray Computed Toxoplasmosis,
Cerebral/BLOOD/*COMPLICATIONS/RADIOGRAPHY T4 Lymphocytes MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).